supersuppressor-1

locus: ssu-1

locus_name: supersuppressor-1

organism_type: B

chromosome_number: VII

chromosome_side: R

link_group: VIIR

cultural_requirements: VIIR. Right of met-7 (14%). Left of nt (23%) and of missense suppressor su(trp-3td201)-1 (10%) (954). Allele WRN33 selected (953) as suppressor of nonsense mutation am(17), which may be either amber or ochre but cannot be UGA (956). Inserts tyrosine in the site where the wild type has glutamate (956). Used to identify suppressible alleles of aro(p), trp-1, trp-2, trp-3 (953, 144, 183), and ad-3B (749). Although perhaps the most efficient of known ssumutations, ssu-1 restores only about 20% of the wild-type amount of normal glutamate dehydrogenase in the double mutant with am allele (17) (reference 956).

enzyme_id:

anid_name:

near_l: met-7 (14%)

near_r: nt (23%) and su(trp-3td201)-1 (10%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #1687	ssu-1;am	Neurospora crassa
FGSC #1688	ssu-1;am	Neurospora crassa
FGSC #6023	ssu-1;nit-3;inl	Neurospora crassa
FGSC #6029	ssu-1;nit-2;inl	Neurospora crassa
FGSC #6030	ssu-1 nit-3	Neurospora crassa

References

Authors	Title	Year
Allen, E. D.	Development of crystalline inclusions ("ergosterol crystals") in N. crassa.	1976
Case, M. E. , and N. H. Giles.	Evidence for nonsense mutations in the arom gene cluster of N. crassa.	1968
Chalmers, J. H. , Jr. , and T. W. Seale.	Supersuppressible mutants in Neurospora:mutants at the tryp-1 and tryp-2 loci affecting thestructure of the multienzyme complex in the tryptophan pathway.	1971
Newcombe, K. D. , and A. J. F. Griffiths.	The suppression of ad-3B mutants by supersuppressors in Neurospora crassa.	1973
Seale, T.	Reversion of the am locus in Neurospora:evidence for nonsense suppression.	1968
Seale, T. W.	Super-suppressors in Neurospora crassa. I. Induction, genetic localization and relationship to a missense suppressor.	1972
Seale, T. W. , M. Brett, A. J. Baron, and J. R. S. Fincham.	Amino acid replacements resulting from suppression and missense reversionof a chain-terminator mutation in Neurospora.	1977