uracil salvage-1

locus: uc-1

locus_name: uracil salvage-1

organism_type: B

chromosome_number: II

chromosome_side:

link_group: II

cultural_requirements: II. Linked to pyr-4 (31%) (1139, 1141). Altered thymidine salvage pathway (Fig. 23). Able to use thymidine, thymine, 5-hydroxy-methyluracil, or 5-formyluracil as the sole pyrimidine source in germinating conidia of pyr-4 mutants, which are blocked in pyrimidine biosynthesis. (In uc-1+ background, pyr-4 can use these compounds only if a primer of uridine or cytidine is supplied [1141]). Causes elevated activities of enzymes which oxidatively demethylate thymine (420).

enzyme_id: 202

Enzyme: none

anid_name:

near_l: Linked to pyr-4 (31%)

near_r:

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2203	pyr-4 uc-1;uc-2	Neurospora crassa
FGSC #2204	uc-1;uc-3;pyr-4	Neurospora crassa

References

Authors	Title	Year
Griswold, W. R. , V. O. Madrid, P. M. Shaffer, D. C. Tappen, C. S. G. Pugh, and M. T. Abbott.	Regulation of thymidine metabolism inNeurospora crassa.	1976
Williams, L. G.	Thymidine metabolism in Neurospora crassa.	1968
Williams, L. G. , and H. K. Mitchell.	Mutants affecting thymidine metabolism in Neurospora crassa.	1969