uracil salvage-4

locus: uc-4

locus_name: uracil salvage-4

organism_type: B

chromosome_number: V

chromosome_side: R

link_group: VR

cultural_requirements: VR. Between inl (12%) and his-6 (11%) (126). Not in I as reported in references 1139 and 1141 on the basis of one ascus in eight recombinant with mt. Thymidine salvage pathway defect (Fig. 23). Unable to use thymidine, thymine, 5-hydroxymethyluracil, 5-formyluracil, or uracil to support pyr-1, even in the presence of a uridine primer (1141). Deficient in phosphoribosyl transferase (127). The uc-4 single mutant converts 50% of the supplied uridine to uracil and excretes it into the medium (1141). Resistant to 5-fluorouracil (126).

enzyme_id: 191

Enzyme: uracil phosphorylase

anid_name:

near_l: inl (12%)

near_r: his-6 (11%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2199	uc-4	Neurospora crassa
FGSC #2200	uc-4	Neurospora crassa
FGSC #4284	udk uc-4	Neurospora crassa
FGSC #4285	udk uc-4	Neurospora crassa

References

Authors	Title	Year
Buxton, F. P. , and A. Radford.	Isolation and mapping of fluoropyrimidine-resistant mutants of N. crassa.	1982
Buxton, F. P. , and A. Radford.	Partial characterization of 5-fluoropyrimidine-resistant mutants of N. crassa.	1982
Williams, L. G. , and H. K. Mitchell.	Mutants affecting thymidine metabolism in Neurospora crassa.	1969