uridine uptake-1

locus: ud-1

locus_name: uridine uptake-1

organism_type: B

chromosome_number: VII

chromosome_side: R

link_group: VIIR

cultural_requirements: VIIR. Between met-7 (27%) and arg-10 (10%) (126). (463). Unable to use pyrimidine nucleosides to support the growth of a pyrimidine auxotroph (pyr-1) although any free pyrimidine base can be used. Probably defective in pyrimidine nucleoside transport (1141) (Fig. 23). Apparently also defective in purine nucleoside transport (224). Resistant to 5-fluorodeoxyuridine and 5-fluorouridine (126). Resistance is recessive in heterokaryons. Shows interallelic complementation (127). Scored by spotting conidial suspension on medium containing 4 x 10(-5)M 5-fluorodeoxyuridine, filter sterilized (463). Mutant gene CIF-dUrd 7, selected by resistance and called fdu-1 (463), is allelic (126). Uridine uptake is decreased by good nitrogen sources and by nit-2 (128).

enzyme_id:

anid_name:

near_l: met-7 (27%)

near_r: arg-10 (10%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2202	ud-1;pyr-1	Neurospora crassa

References

Authors	Title	Year
Buxton, F. P. , and A. Radford.	Isolation and mapping of fluoropyrimidine-resistant mutants of N. crassa.	1982
Buxton, F. P. , and A. Radford.	Partial characterization of 5-fluoropyrimidine-resistant mutants of N. crassa.	1982
Buxton, F. P. , and A. Radford.	Nitrogen metabolic repression of fluoropyrimidine resistance and pyrimidine uptake in N. crassa.	1982
Dalke, A. P.	The transport and utilization of purine and pyrimidine nucleosides and bases by germinating conidia of N. crassa.	1980
Hoffman, G. R. , H. V. Malling, and T. J. Mitchell.	Genetics of 5-fluorodeoxyuridine-resistant mutants of Neurospora crassa.	1973
Williams, L. G. , and H. K. Mitchell.	Mutants affecting thymidine metabolism in Neurospora crassa.	1969