uridine kinase

locus: udk

locus_name: uridine kinase

organism_type: B

chromosome_number: V

chromosome_side: R

link_group: VR

cultural_requirements: VR. Left of uc-4 (29%) (126). Deficient in uridine kinase (127) (Fig. 23). The udk uc-4 double mutant is resistant to 5-fluoro-deoxyuridine and 5-fluorouridine (126), but the udk single mutant is not resistant to any analog. Uracil salvage pathway, by which many exogenously supplied pyrimidines are cycled via uracil to uridine 5'-phosphate and, thus, into the latter part of the pyrimidine biosynthetic pathway. The figure shows the sites of action of the salvage pathway uc genes, the ud and uc-5 genes, which control uptake of exogenous uridine and uracil, and udk, which controls uridine kinase (126, 420, 616, 977, 1141). For endogenous pyrimidine synthesis, see Fig. 20.

enzyme_id:

anid_name:

near_l:

near_r: uc-4 (29%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #4284	udk uc-4	Neurospora crassa
FGSC #4285	udk uc-4	Neurospora crassa

References

Authors	Title	Year
Buxton, F. P. , and A. Radford.	Isolation and mapping of fluoropyrimidine-resistant mutants of N. crassa.	1982
Buxton, F. P. , and A. Radford.	Partial characterization of 5-fluoropyrimidine-resistant mutants of N. crassa.	1982
Griswold, W. R. , V. O. Madrid, P. M. Shaffer, D. C. Tappen, C. S. G. Pugh, and M. T. Abbott.	Regulation of thymidine metabolism inNeurospora crassa.	1976
Liu, C. -K. , C. -A. Hsu, and M. T. Abbott.	Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase.	1973
Shaffer, P. M. , C. -A. Hsu, and M. T. Abbott.	Metabolism of pyrimidine deoxyribonucleosides in Neurospora crassa.	1975
Williams, L. G. , and H. K. Mitchell.	Mutants affecting thymidine metabolism in Neurospora crassa.	1969