UV sensitive-6

locus: uvs-6

locus_name: UV sensitive-6

organism_type: B

chromosome_number: I

chromosome_side: R

link_group: IR

cultural_requirements: IR. Between thi-1 (3 to 8%) and ad-9 (4%) (538; E. Kafer, personal communication; D. Newmeyer, unpublished data). Very close to met-6 (< 1%) (D. Newmeyer, unpublished data). (937). Increases sensitivity to UV (273, 937), ionizing radiation (537, 937, 940), nitrosoguanidine (509, 537), histidine (755), methyl methane sulfonate (536), ICR-170 and 4-nitroquinoline 1-oxide (509), and possibly mitomycin C (537). Normal UV-induced mutation (273). For mutation induction by other agents, see references 509 and 940. Increased spontaneous mutation not evident in the ad-3 system (275), but is found for recessive lethals in a heterokaryon test system (E. Kafer, personal communication). Normal dimer excision (1164). Defective in extracellular nuclease, giving reduced halos around colonies on DNA agar (538). Increased duplication instability due to mitotic recombination, deletion, or both (759). Homozygous barren (759), with a block at crozier differentiation (860). Reduced conidial viability (537). Switches to stop-start growth after initial normal growth (D. Newmeyer, unpublished data). Not completely recessive in heterokaryotic conidia (979). Increased stability of CPS (Pyr) activity in vitro suggests that protease activity may be reduced in the mutant uvs-6 (882); see also reference 360. Double mutant uvs-3;uvs-6 is inviable (506).

enzyme_id: 202

Enzyme: none

anid_name:

near_l: thi-1 (3 to 8%)

near_r: ad-9 (4%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2244	Has been replaced by strain number: 4178	Neurospora crassa
FGSC #2245	Has been replaced by strain number: 4179	Neurospora crassa
FGSC #4178	uvs-6	Neurospora crassa
FGSC #4179	uvs-6	Neurospora crassa
FGSC #4198	This strain is not available uvs-6;mtr met-2 pan-1	Neurospora crassa
FGSC #4199	uvs-6;nic-3	Neurospora crassa
FGSC #4776	pan-2;al-2;cot-1;uvs-6	Neurospora crassa
FGSC #4777	pan-2;al-2;cot-1;uvs-6	Neurospora crassa

References

Authors	Title	Year
De Serres, F. J.	Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. II. Comparison ofdose-response curves for inactivation and mutation induced aby UV.	1980
De Serres, F. J. , H. Inoue, and M. E. Schpbach.	Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains ofNeurospora crassa. I. Development of isogenic strains and spontaneous mutability.	1980
Inoue, H. , R. C. Harvey, D. F. Callen, and F. J. de Serres.	Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains ofNeurospora crassa. V. Comparison of dose-response curves of single- and double-mutant strains with wild type.	1981
Inoue, H. , T. M. Ong, and F. J. de Serres.	Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurosporacrassa. IV. Comparison of dose-response curves for MNNG, 4NQO and ICR-170 induced inactivation and mutation-induction.	1981
Kafer, E.	Sensitivity to methyl-methane sulfonate (MMS) in Neurospora.	1978
Kafer, E.	Mutagen sensitivities and mutator effects of MMS-sensitive mutants in Neurospora.	1981
Kafer, E. , and M. Fraser.	Isolation and genetic analysis of nuclease halo (nuh) mutants of Neurospora crassa.	1979
Newmeyer, D.	A suppressor of the heterokaryon-incompatibility associated with mating type in Neurospora crassa.	1970
Newmeyer, D. , A. L. Schroeder, and D. R. Galeazzi.	An apparent connection between histidine, recombination, and repair inNeurospora.	1978
Raju, N. B. , and D. D. Perkins.	Barren perithecia in Neurospora crassa.	1978
Rigby, D. J. , and A. Radford.	The involvement of proteolysis in conformational stability of the carbamoyl-phosphatesynthetase/aspartate carbamoyltransferase enzyme of Neurospora crassa.	1981
Schroeder, A. L. , F. J. de Serres, and M. E. Schpbach.	A new ultraviolet-light-sensitive mutant in Neurospora, uvs-6.	1972
Schpbach, M. E. and F. J. de Serres.	Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. III. Comparison of dose-response curves for inactivation and mutation induced by gamma rays.	1981
Shelby, M. D. , F. J. de Serres, and G. J. Stine.	Ultraviolet-inactivation of conidia from heterokaryons of Neurospora crassa containingUV-sensitive mutations.	1975
Worthy, T. E. , and J. L. Epler.	Biochemical basis of radiation-sensitivity in mutants of Neurospora crassa.	1973
Schroeder		1986