methionine(105W)

locus: met(105W)

locus_name: methionine(105W)

organism_type: B

chromosome_number:

chromosome_side:

link_group:

cultural_requirements: Auxotrophs designated met require methionine, and some can use its immediate precursors, homocysteine and cystathionine; they cannot use cysteine. (Mutants able to use cysteine as well as methionine are designated cys.) For the methionine biosynthetic pathway, see Fig. 17. For a review, see reference 351. For regulation, see individual loci and reference 965. Formerly called me. Biosynthetic pathways of homoserine, threonine, and methionine, showing sites of gene action (124, 208, 209, 351, 352, 518, 547, 965). For conversion of threonine to isoleucine, see Fig. 15. H4PteGlu, Tetrahydrofolate. It is not clear whether the polyglutamylation step controlled by met-6 occurs only at the stage shown.

enzyme_id:

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neu_name:

supplement: methionine

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Strains

FGSC #	Reporting Genes	Species
FGSC #3764	met(105W);inl	Neurospora crassa

References

Authors	Title	Year
Burton, E. G. , and R. L. Metzenberg.	Regulation of methionine biosynthesis in N. crassa.	1975
Cossins, E. A. , and P. -Y. Chan.	Folylpolyglutamate synthetase activities of N. crassa:Nature of products formed by soluble andparticulate enzymes in the wild type and polyglutamatedeficient mutants.	1982
Cossins, E. A. , P. -Y. Chan, and G. Combepine.	One-carbon metabolism in N. crassa wild type and in mutants partially deficient inserine hydroxymethyltransferase.	1976
Flavin, M.	Methionine biosynthesis.	1975
Flavin, M. , and C. Slaughter.	Purification and properties of threonine synthetase of Neurospora.	1960
Jenkins, M. B. , and H. R. Garner.	Studies of a homoserineless bradytroph of Neurospora crassa:demonstration of an alteredaspartate beta-semialdehyde dehydrogenase.	1967
Kerr, D. S. , and M. Flavin.	The regulation of methionine synthesis and the nature of cystathionine-synthase in Neurospora.	1970
Selhub, J. , M. A. Savin, W. Sakami, and M. Flavin.	Synchronization of converging metabolic pathways:activation of thecystathionine- -synthase of Neurospora crassa by methyltetrahydrofolate.	1971