methylpurine resistant

locus: mep(10)

locus_name: methylpurine resistant

organism_type: B

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cultural_requirements: Not mapped. Segregates 1:1. Resistant to 6-methylpurine. Adenine phosphoribosyltransferase activity is negligible in vitro. Adenine uptake is normal. Resistance may result from inability to convert the analog to nucleotide form. Has low hypoxanthine phosphoribosyltransferase activity, as do the mutants mep(3) and ad-8, q.v. Selected on 1 mM 6-methylpurine-sorbose medium. Not tested for allelism with mep(3). Called Mepr-10, but not indicated to be dominant. (785) Called mep-2 by Barratt and Ogata (51).

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Strains

FGSC #	Reporting Genes	Species
FGSC #8914	mepR(10) his-3; inl^[(SadI-BglII)::lambda A]	Neurospora crassa

References

Authors	Title	Year
Ahmad, M. , M. U. Ahmad, and A. Zaman.	Mapping of locus lysine-2 in N. crassa.	1966
Barratt, R. W. , and W. N. Ogata.	Neurospora stock list:10th revision (June 1980).	1980
Pendyala, L. , J. Smyth, and A. M. Wellman.	Nature of 6-methylpurine inhibition and characterization of two 6-methylpurine-resistantmutants of Neurospora crassa.	1979