Gene: methylpurine resistant
methylpurine resistant
locus: mep(3)
locus_name: methylpurine resistant
organism_type: B
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cultural_requirements: Not mapped. Segregates 1:1. Resistant to 6-methylpurine. Adenine phosphoribosyltransferase activity near normal in vitro. Uptake is normal. 6-Methylpurine prevents purple pigment production by ad-3 single mutants on low adenine concentrations, but it does not prevent pigment production by the ad3A;mep(3) double mutant, suggesting that mep(3) results in an alteration in the regulation of de novo purine synthesis. Has low hypoxanthine phosphoribosyltransferase activity, as do mep(10) and ad-8 mutants, q.v. Selected on 1 mM 6-methylpurine-sorbose medium (785). Phenotype consistent with lowered affinity of glutamine amidotransferase for 6-methylpurine as a feedback inhibitor (788). Not tested for allelism with mep(10) or with ad mutations. Called Mepr-3, but not indicated to be dominant (785). Called mep-1by Barratt and Ogata (51).
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Strains
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References
