Gene: adenine
adenine
locus: ad
locus_name: adenine
organism_type: B
chromosome_number:
chromosome_side:
link_group:
cultural_requirements: For the purine biosynthetic pathway, see Fig. 8. (For the abbreviations used below, see the legend to Fig. 8.) For the interrelationship of purine, histidine, and tryptophan pathways, see reference 786. The growth of mutants in the terminal (post-AICAR) steps of the adenine biosynthetic pathway is aided by histidine, which has a sparing effect on ad-1, ad-4, and ad-8 (661; M.E. Case, personal communication). Mutants carrying some ad-5alleles are aided by histidine; others are inhibited (M.E. Case, personal communication). Indole may strongly inhibit adenine mutants (595). Strains carrying mutations at loci ad-3A and ad-3B accumulate purple (red) pigment when adenine is limiting; see the ad-3B entry. Smaller amounts of the pigment may be seen in strains carrying other post-AIR genes such as ad-4 and ad-5 (526, 682). Pigment may be polymerized AIR (786). Mutant genes affecting earlier biosynthetic steps are epistatic to ad-3 and later mutant genes with respect to pigment production (526). ad-3B (and presumably also ad-3A) stocks accumulate spontaneous mutations at other ad loci, which prevent pigment production and improve the growth rate (691). ad-3B, ad-4, ad-8, and ad-9mutants have been used to study the effect of histidine on purine pool utilization (786). Regulation of purine catabolism reviewed in reference 642. Regulation of purine biosynthesis (405a, 788). Adenine mutations at the various loci were assigned to complementation groups designated by capital letters (526). The relationships of most of these groups to steps of the biosynthetic pathway are given in Fig. 10 of reference 120.
enzyme_id:
anid_name:
near_l:
near_r:
neu_name:
supplement: adenine
image_url:
Strains
| FGSC # | Reporting Genes | Species |
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References
