Transport mutants

locus: Transport mutants

locus_name: Transport mutants

organism_type: B

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cultural_requirements: Mutations affecting transport have been obtained by many techniques, using metabolites, antimetabolites, etc. Nomenclature has consequently been chaotic. Transport mutations are listed under the following entries. (i) Amino acid transport: Basic (pmb, = bat); neutral (mtr, = pmn); and general [pmg; see also su(mtr)-1]. Individual genes have been symbolized (e.g., references 248 and 1152) as pm b or Pm- B, and compound mutants, such as pmn;pmb, have been symbolized pm nb or Pm- NB. Symbols in the present article are changed from this nomenclature so as to show that pmn and pmb are separate genes. Other mutant genes that may involve amino acid transport are argR, lysR, hlp-1, and hlp-2. (ii) Transport or possible transport mutations for other metabolites or ions: acpi, car, cys-13, cys-14, fpr, glt, ipm-1, ipm-2, mea-1, sit, sor, trk, tys, uc-5, and ud-1. (iii) Mutations that appear to affect more than one transport system: hgu-4, nap, fpr-6, mod-5, mts, and un-3; see especially reference 1149. (iv) There are also general regulatory loci that control many related enzymes including the relevant permeases, e.g., nit-2, cys-3, pcon (nuc-2), preg, pgov, and nuc-1. Transport of various ions and compounds is reviewed in references 406 and 921; amino acid transport is reviewed in reference 1150, and peptide transport is reviewed in reference 1151.

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Strains

References