UV sensitive

locus: uvs

locus_name: UV sensitive

organism_type: B

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cultural_requirements: uvs and other radiation-sensitive mutants are highly pleiotropic, with phenotypic spectra that may (or may not) include: sensitivity to ionizing radiation, radiomimetic chemicals, mitomycin C, or histidine; impairment of meiosis; increased frequency of deletion or mitotic recombination; increased spontaneous or induced mutation; defective DNA repair; altered secretion of deoxyribonuclease. Sensitivity is typically recessive. The most sensitive Neurospora mutant, uvs-2, is only 20 times more sensitive than the wild type to UV (935). The more general name, mus (mutagen sensitive), has been adopted for mutant loci beyond uvs-6(537). Several UV-sensitive mutants have names other than uvs or mus: see gs(6), Mei-2, mei-3, nuh-4, upr-1. Scoring is most readily accomplished by spot tests, i.e., spotting conidial suspensions on the surface of prepoured plates that contain sorbose (536, 932, 1023) and comparing growth on exposed and control plates. Properties of the uvs mutants are summarized in references 509, 537, 936, and 938. For properties of double mutants, see references 506, 539, and 1095.

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Strains

FGSC #	Reporting Genes	Species

References

Authors	Title	Year
Ahmad, M. , and S. Haque.	A more precise mapping of tryp-5 in N. crassa.	1980
Kafer, E.	Sensitivity to methyl-methane sulfonate (MMS) in Neurospora.	1978
Kafer, E.	Mutagen sensitivities and mutator effects of MMS-sensitive mutants in Neurospora.	1981
Schroeder, A. L.	Ultraviolet-sensitive mutants of Neurospora. I. Genetic basis and effect on recombination.	1970
Schroeder, A. L.	Properties of a UV-sensitive Neurospora strain defective in pyrimidine dimer excision.	1974
Stadler, D. R. , and D. A. Smith.	A new mutation in Neurospora for sensitivity to ultraviolet.	1968