colonial temperature sensitive-2

locus: cot-2

locus_name: colonial temperature sensitive-2

organism_type: B

chromosome_number: V

chromosome_side: R

link_group: VR

cultural_requirements: VR. Right of pk (8%) and ser-2 (5%). Left of ad-7(4%) (156, 818). (698) Recombines with inv (5%) (315).Small colonies at 34°C but fully viable. Growth and morphology nearly normal at 25°C but not completely so (382). Makes altered invertase; it is not clear whether cot-2 is the structural gene for a second subunit or whether cot-2affects structure indirectly, e.g., by altering the carbohydrate moiety (315). See inv. Reduced amount of cell wall peptides (1165). Ascospores are normal in heterozygous crosses, but are round in homozygous cot-2 x cot-2crosses (59). Some cot-2 strains carry mei-3, which was found in the original cot-2 strain (757); however, most strains used by Eggerding et al. (315) are free of it, and mei-3 cannot be responsible for the effects on invertase (D. Newmeyer, unpublished data).

enzyme_id: 202

Enzyme: none

anid_name:

near_l: pk (8%) and ser-2 (5%)

near_r: ad-7(4%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #1512	Has been replaced by strain number: 2263	Neurospora crassa
FGSC #1513	cot-2	Neurospora crassa
FGSC #2263	cot-2	Neurospora crassa
FGSC #4653	cot-2;eas	Neurospora crassa
FGSC #4654	cot-2;eas	Neurospora crassa

References

Authors	Title	Year
Barry, E. G. , D. Newmeyer, D. D. Perkins, and B. C. Turner.	Genetically determined round ascospores in N. crassa.	1972
Catcheside, D. E. A.	New linkage data for group V markers in N. crassa.	1973
Eggerding, C. , J. A. Randall and M. L. Sargent.	An altered invertase in the cot-2 mutant of Neurospora crassa.	1975
Garnjobst, L. , and E. L. Tatum.	A survey of new morphological mutants in Neurospora crassa.	1967
Morgan, M. P. , L. Garnjobst, and E. L. Tatum.	Linkage relations of new morphological mutants in linkage group V of Neurosporacrassa.	1967
Newmeyer, D. , and D. R. Galeazzi.	A meiotic UV-sensitive mutant that causes deletion of duplications in Neurospora.	1978
Perkins, D. D. , M. R. Smith, and D. R. Galeazzi.	New markers and linkage data.	1973
Wrathall, C. R. , and E. L. Tatum.	Hyphal wall peptides and colonial morphology in Neurospora crassa.	1974