ergosterol-1

locus: erg-1

locus_name: ergosterol-1

organism_type: B

chromosome_number: V

chromosome_side: R

link_group: VR

cultural_requirements: VR. Between pk (2%) and asn (9%) (419).The cell membrane is deficient in ergosterol, conferring strong resistance to nystatin and other polyene antibiotics (418, 419). Defective in conversion of fecosterol to episterol (Fig. 13.). Lacks fecosterol delta8,delta7-isomerase (419). Infertile as female. Slow growth, reduced conidiation. The nysrmutants of reference 699 are blocked in the same reaction, but nysr has not been tested for allelism with erg-1.

enzyme_id: 103

Enzyme: fecosterol isomerase

anid_name:

near_l: pk (2%)

near_r: asn (9%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2721	erg-1	Neurospora crassa
FGSC #2722	erg-1;pan-2	Neurospora crassa

References

Authors	Title	Year
Grindle, M.	The efficacy of various mutagens and polyene antibiotics for the induction and isolation of sterol mutants ofNeurospora crassa.	1974
Grindle, M. , and R. Farrow.	Sterol content and enzyme defects of nystatin-resistant mutants of Neurospora crassa.	1978