ergosterol-2

locus: erg-2

locus_name: ergosterol-2

organism_type: B

chromosome_number: V

chromosome_side: R

link_group: VR

cultural_requirements: VR. Left of inl (6%) (419). The cell membrane is deficient in ergosterol, thereby conferring slight resistance to nystatin and other polyene antibiotics (417, 418). Lacks 24(28)dehydroergosterol hydrogenase (terminal step of ergosterol synthesis) (419) (Fig. 13.). Poorly fertile as female. Good growth and conidiation.

enzyme_id: 2

Enzyme: 24(28)dehydroergosterol hydrogenase

anid_name:

near_l:

near_r: inl (6%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2723	erg-2	Neurospora crassa
FGSC #2724	erg-2;pan-2	Neurospora crassa

References

Authors	Title	Year
Antoine, A. D.	Purification and properties of the nitrate reductase isolated from N. crassa mutant nit-3. Kinetics, molecular weightdetermination, and cytochrome involvement.	1974
Grindle, M.	Sterol mutants of Neurospora crassa:their isolation, growth characteristics and resistance to polyene antibiotics.	1973
Grindle, M.	The efficacy of various mutagens and polyene antibiotics for the induction and isolation of sterol mutants ofNeurospora crassa.	1974
Grindle, M. , and R. Farrow.	Sterol content and enzyme defects of nystatin-resistant mutants of Neurospora crassa.	1978