ethionine resistant

locus: eth-1

locus_name: ethionine resistant

organism_type: B

chromosome_number: I

chromosome_side: L

link_group: IL

cultural_requirements: IL. Between arg-1 and arg-3 (1%) (816). (672)Resistant to ethionine at 24°C (672). Labile S-adenosylmethionine synthetase (515, 547) (see Fig. 17). Resistance attributed to overproduction of methionine (541, 542). Heat sensitive; no growth at 37°C (672). Levels of several enzymes that are normally repressible by methionine are not repressed by methionine in eth-1R strains even at the growth-permissive temperature (124, 664). See also reference 965. Both heat sensitivity and ethionine resistance are reparable by high osmotic pressure (664). Called r-eth-1.

enzyme_id: 36

Enzyme: S-adenosylmethionine synthetase

anid_name: mecC

near_l: arg-1

near_r: arg-3 (1%)

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #1212	eth-1	Neurospora crassa
FGSC #1220	eth-1	Neurospora crassa

References

Authors	Title	Year
Burton, E. G. , and R. L. Metzenberg.	Regulation of methionine biosynthesis in N. crassa.	1975
Jacobson, E. S. , G. S. Chen, and R. L. Metzenberg.	Unstable S-adenosylmethionine synthetase in an ethionine-resistant strain ofNeurospora crassa.	1977
Kappy, M. S.	Studies on the basis of ethionine resistance in Neurospora crassa.	1967
Kappy, M. S. , and R. L. Metzenberg.	Studies on the basis of ethionine-resistance in Neurospora.	1965
Kerr, D. S. , and M. Flavin.	The regulation of methionine synthesis and the nature of cystathionine-synthase in Neurospora.	1970
Metzenberg, R. L.	Repair of multiple defects of a regulatory mutant of Neurospora by high osmotic pressure and by reversion.	1968
Metzenberg, R. L. , M. S. Kappy, and J. W. Parson.	Irreparable mutations and ethionine resistance in Neurospora.	1964
Perkins, D. D. , D. Newmeyer, C. W. Taylor, and D. C. Bennett.	New markers and map sequences in Neurospora crassa, with adescription of mapping by duplication coverage, and of multiple translocation stocks for testing linkage.	1969