formate

locus: for

locus_name: formate

organism_type: B

chromosome_number: VII

chromosome_side: R

link_group: VIIR

cultural_requirements: VIIR. Right of wc-1 (5%) and frq (3%). Left of dr (3%) (812, 819; J. F. Feldman, personal communication).Requires formate or formaldehyde. Growth aided slightly if glycine, histidine, or choline is added to formate (446). Will also grow on a mixture of methionine and adenine and suboptimally on adenine alone (446). Lacks cytosolic (but not mitochondrial) serine hydroxymethyl- transferase (Fig. 17) (124, 210). Has increased formyl tetrahydrofolate synthetase, methylene tetrahydrofolate dehydrogenase, isocitrate lyase, and glyoxalate aminotransferase activities (209, 210). Use 0.3 mg of formate per ml. Can be autoclaved.

enzyme_id: 90

Enzyme: cytosolic serine hydoxymethyltransferase

anid_name:

near_l: wc-1 (5%) and frq (3%)

near_r: dr (3%)

neu_name:

supplement: ( formate and ( glycine or histidine or choline ) ) or formaldehyde or ( methionine and adenine )

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #9	for	Neurospora crassa
FGSC #133	Has been replaced by strain number: 3850	Neurospora crassa
FGSC #3850	for	Neurospora crassa
FGSC #8611	for	Neurospora crassa

References

Authors	Title	Year
Burton, E. G. , and R. L. Metzenberg.	Regulation of methionine biosynthesis in N. crassa.	1975
Cossins, E. A. , P. -Y. Chan, and G. Combepine.	One-carbon metabolism in N. crassa wild type and in mutants partially deficient inserine hydroxymethyltransferase.	1976
Cossins, E. A. , and S. H. Y. Pang.	Loss of cytosolic serine hydroxymethyltransferase in a formate mutant of N. crassa.	1980
Harrold, C. E. , and M. Fling.	Two mutants of Neurospora crassa which utilize formate or formaldehyde for growth.	1952
Perkins, D. D. , M. Glassey, and B. A. Bloom.	New data on markers and rearrangements in Neurospora.	1962
Perkins, D. D. , C. W. Taylor, D. C. Bennett, and B. C. Turner.	New morphological mutants that have been localized to linkage group.	1969