guanine-1

locus: gua-1

locus_name: guanine-1

organism_type: B

chromosome_number: I

chromosome_side:

link_group: I

cultural_requirements: 1. Linked to arg-3 (8%) (1171); probably between his-2(3%) and cr-1 (3%) (PB).Requires guanine. Inhibited (competitively) by adenine and by complex complete medium. Adapts phenotypically after several days and grows up on minimal or complete medium, but retains the requirement on subculture. Adenine prevents or decreases adaptation. Guanosine is preferred to guanine as a supplement because of greater solubility. Best scored at 2 and 3 days on slants of minimal medium plus 1 mg of adenine versus minimal medium plus 0.2 mg of guanosine per ml. (1171) Deficient in inosine 5'-mono-phosphate dehydrogenase (10% of the wild-type level with allele OY301) (405a) (Fig. 8).

enzyme_id: 125

Enzyme: inosine 5'-monophosphate dehydrogenase

anid_name:

near_l: Linked to arg-3 (8%)

near_r:

neu_name:

supplement: guanine

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #3524	gua-1	Neurospora crassa
FGSC #3525	gua-1	Neurospora crassa

References

Authors	Title	Year
Yoder, O. C.	Guanine-requiring mutants.	1979
Greer, W. L.	Guanosine metabolism in Neurospora crassa.	1981