Gene: histidine-3 IR

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histidine-3

locus: his-3

locus_name: histidine-3

organism_type: B

chromosome_number: I

chromosome_side: R

link_group: IR

cultural_requirements: IR. Right of met-10 (R.L. Metzenberg, personal communication). Left of cog (1 to 3%) (172,174), ure-4 (1%) (78), and ad-3A (1%) (271). (434)Requires histidine (434). Complex gene coding for histidinol dehydrogenase, phosphoribosyladenosine 5'-triphosphate-pyrophosphohydrolase, and phosphoribosyl-adenosine 5'-monophosphate-cyclohydrolase (16, 673) (Fig. 14). All three activities appear to be catalyzed by a single protein (673). Strains carrying different individual alleles may lack only the early reaction(s) or only histidinol dehydrogenase, or both. Those that lack only histidinol dehydrogenase accumulate histidinol (16, 162, 1123). Mutants produce cross-reacting material (220). Used to study intralocus complementation and recombination (15, 16, 27, 162, 164, 171, 172, 1121, 1122, 1124). Intralocus recombination is regulated by cog and by rec-2 (27, 171); it is not affected by rec-1 (172). Translocation T(IR;VII)TM429, with one breakpoint in his-3, has been used to show that cog is cis-acting (171). Initial alleles: C140 and T1710 (= C1710).

enzyme_id: 116

Enzyme: histidinol dehydrogenase

anid_name: hisD

near_l: met-10

near_r: cog (1 to 3%)

neu_name:

supplement: histidine

image_url:

Strains

FGSC # Reporting Genes Species
FGSC #206his-3 ptNeurospora crassa
FGSC #356Has been replaced by strain number: 2277Neurospora crassa
FGSC #387sn his-3Neurospora crassa
FGSC #455his-3Neurospora crassa
FGSC #460Has been replaced by strain number: 4496Neurospora crassa
FGSC #462his-3Neurospora crassa
FGSC #715Has been replaced by strain number: 1682Neurospora crassa
FGSC #716his-3Neurospora crassa
FGSC #717his-3Neurospora crassa
FGSC #718his-3Neurospora crassa
FGSC #719his-3Neurospora crassa
FGSC #720his-3Neurospora crassa
FGSC #734his-3Neurospora crassa
FGSC #1153his-3Neurospora crassa
FGSC #1154his-3Neurospora crassa
FGSC #1155his-3Neurospora crassa
FGSC #1156Not availableNeurospora crassa
FGSC #1157his-3Neurospora crassa
FGSC #1158his-3Neurospora crassa
FGSC #1682his-3Neurospora crassa
FGSC #1855his-3 nic-2Neurospora crassa
FGSC #2277his-3Neurospora crassa
FGSC #2278his-3Neurospora crassa
FGSC #2319hlp-2;his-3Neurospora crassa
FGSC #2320hlp-1;ff-1;his-3Neurospora crassa
FGSC #2457his-3 nic-2 al-2;pan-2Neurospora crassa
FGSC #2530T(I;VII)TM429 his-3Neurospora crassa
FGSC #2531T(I;VII)TM429 his-3Neurospora crassa
FGSC #2563rec-2;cog+;cot-1;arg-1 his-3Neurospora crassa
FGSC #2564rec-2;cog+;cot-1;his-3Neurospora crassa
FGSC #2565rec-2;cog;cot-1;his-3 ad-3Neurospora crassa
FGSC #2566rec-2;cog;cot-1;his-3 ad-3Neurospora crassa
FGSC #2567rec-2;cot+;cot-1;his-3 ad-3Neurospora crassa
FGSC #2568rec-2;cog+;cot-1;arg-1 his-3Neurospora crassa
FGSC #2569rec-2;cog;cot-1;his-3 ad-3Neurospora crassa
FGSC #2570rec-2;cog;cot-1;arg-1 his-3Neurospora crassa
FGSC #2571rec-2;cog;cot-1;arg-1 his-3Neurospora crassa
FGSC #2572rec-2;cog+;cot-1;his-3;amNeurospora crassa
FGSC #2573rec-2;cog+;cot-1;arg-1 his-3Neurospora crassa
FGSC #2574rec-2;cot+;cot-1;arg-1 his-3Neurospora crassa
FGSC #3271his-3;basaNeurospora crassa
FGSC #3272neua;his-3Neurospora crassa
FGSC #3273neur;his-3Neurospora crassa
FGSC #3918Has been replaced by strain number: 5264Neurospora crassa
FGSC #4438his-3Neurospora crassa
FGSC #4495his-3Neurospora crassa
FGSC #4496his-3Neurospora crassa
FGSC #4770Not available rg-1 his-3 nic-2Neurospora crassa
FGSC #5040his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5060his-3Neurospora crassa
FGSC #5081Replaced with 5971Neurospora crassa
FGSC #5084Replaced with 5899Neurospora crassa
FGSC #5088Replaced with 6671Neurospora crassa
FGSC #5264his-3 nic-2 al-2;pan-2Neurospora crassa
FGSC #5265his-3 nic-2 al-2;pan-2Neurospora crassa
FGSC #5274his-3;cot-1Neurospora crassa
FGSC #5275his-3 nic-2;pan-2;cot-1Neurospora crassa
FGSC #5276his-3 nic-2;pan-2;cot-1Neurospora crassa
FGSC #5506his-3 al-1;mtr col-4 cot-1Neurospora crassa
FGSC #5507his-3 al-1;mtr col-4 cot-1Neurospora crassa
FGSC #5526arg-3 his-3 nic-2(?)Neurospora crassa
FGSC #5531his-3;inlNeurospora crassa
FGSC #5544arg-3 his-3 nic-2 al-1Neurospora crassa
FGSC #5545his-3 nic-2 al-1Neurospora crassa
FGSC #5546arg-3 his-3 nic-2 al-1;inlNeurospora crassa
FGSC #5549arg-3 his-3 nic-2 al-1;inlNeurospora crassa
FGSC #5550his-2 his-3 nic-2 al-1Neurospora crassa
FGSC #5551his-2 his-3 nic-2 al-1Neurospora crassa
FGSC #5558his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5559his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5560his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5561his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5562his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5563his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5564his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5565his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5566his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5567his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5568his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5569his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5570his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5571his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5572his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5573his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5574his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5575his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5576his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5577his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5578his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5579his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5580his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5581his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5582his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5583his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5584his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5585his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5586his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5587his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5590his-3 al-1;ad-2;cot-1Neurospora crassa
FGSC #5595Has been replaced by strain number: 9999Neurospora crassa
FGSC #5596his-3 al-1;ad-2;col-4;cot-1Neurospora crassa
FGSC #5601his-3 al-1;ad-2;mtr col-4Neurospora crassa
FGSC #5602his-3 al-1;ad-2;mtr col-4 cot-1Neurospora crassa
FGSC #5603his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5604his-3 al-1;mtr col-4 cot-1Neurospora crassa
FGSC #5613Not available; his-3Neurospora crassa
FGSC #5663his-3 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #5844his-3 al-1;ad-2Neurospora crassa
FGSC #5845his-3 al-1;ad-2;mtr col-4 cot-1Neurospora crassa
FGSC #5846arg-3 his-3 nic-2 al-1;cot-1;pan-2Neurospora crassa
FGSC #5847arg-3 his-3 nic-2 al-1;cot-1;pan-2Neurospora crassa
FGSC #5848arg-3 his-3 nic-2 al-1;cot-1;pan-2Neurospora crassa
FGSC #5849arg-3 his-3 nic-2 al-1;cot-1;pan-2Neurospora crassa
FGSC #5855his-3 nic-2 al-2;cot-1;pan-2Neurospora crassa
FGSC #5856his-3 nic-2 al-2;cot-1;pan-2Neurospora crassa
FGSC #5857his-3 nic-2 al-2;cot-1;inl;pan-2Neurospora crassa
FGSC #6031his-3Neurospora crassa
FGSC #6032his-3Neurospora crassa
FGSC #6033Replaced with 6694Neurospora crassa
FGSC #6034his-3Neurospora crassa
FGSC #6035his-3Neurospora crassa
FGSC #6044his-3Neurospora crassa
FGSC #6045his-3Neurospora crassa
FGSC #6046his-3Neurospora crassa
FGSC #6047his-3Neurospora crassa
FGSC #6048his-3Neurospora crassa
FGSC #6049his-3Neurospora crassa
FGSC #6050his-3 ylo?Neurospora crassa
FGSC #6051his-3Neurospora crassa
FGSC #6052his-3Neurospora crassa
FGSC #6053his-3Neurospora crassa
FGSC #6054his-3Neurospora crassa
FGSC #6055his-3Neurospora crassa
FGSC #6056his-3Neurospora crassa
FGSC #6057his-3Neurospora crassa
FGSC #6058his-3Neurospora crassa
FGSC #6059his-3Neurospora crassa
FGSC #6060his-3Neurospora crassa
FGSC #6061Replaced with 6698Neurospora crassa
FGSC #6062his-3Neurospora crassa
FGSC #6063Replaced with 6697Neurospora crassa
FGSC #6064his-3Neurospora crassa
FGSC #6065his-3Neurospora crassa
FGSC #6066his-3Neurospora crassa
FGSC #6067his-3Neurospora crassa
FGSC #6068his-3Neurospora crassa
FGSC #6069his-3Neurospora crassa
FGSC #6070his-3Neurospora crassa
FGSC #6071his-3Neurospora crassa
FGSC #6072his-3Neurospora crassa
FGSC #6073his-3Neurospora crassa
FGSC #6074his-3Neurospora crassa
FGSC #6075his-3Neurospora crassa
FGSC #6076his-3Neurospora crassa
FGSC #6077his-3Neurospora crassa
FGSC #6078his-3Neurospora crassa
FGSC #6079his-3Neurospora crassa
FGSC #6080his-3Neurospora crassa
FGSC #6081his-3Neurospora crassa
FGSC #6082his-3Neurospora crassa
FGSC #6083his-3Neurospora crassa
FGSC #6084his-3Neurospora crassa
FGSC #6085his-3Neurospora crassa
FGSC #6086his-3Neurospora crassa
FGSC #6087his-3Neurospora crassa
FGSC #6088Replaced with 6693Neurospora crassa
FGSC #6089his-3Neurospora crassa
FGSC #6090his-3Neurospora crassa
FGSC #6091his-3Neurospora crassa
FGSC #6092his-3Neurospora crassa
FGSC #6093his-3Neurospora crassa
FGSC #6094his-3Neurospora crassa
FGSC #6095his-3Neurospora crassa
FGSC #6096his-3Neurospora crassa
FGSC #6097his-3Neurospora crassa
FGSC #6098his-3Neurospora crassa
FGSC #6099his-3Neurospora crassa
FGSC #6100his-3Neurospora crassa
FGSC #6101his-3Neurospora crassa
FGSC #6102his-3Neurospora crassa
FGSC #6103his-3Neurospora crassa
FGSC #6104his-3Neurospora crassa
FGSC #6105his-3Neurospora crassa
FGSC #6106his-3Neurospora crassa
FGSC #6107his-3Neurospora crassa
FGSC #6108his-3 ad-6Neurospora crassa
FGSC #6109his-3 ad-6Neurospora crassa
FGSC #6110his-3 ad-6Neurospora crassa
FGSC #6111his-3 ad-6Neurospora crassa
FGSC #6112his-3 ad-6Neurospora crassa
FGSC #6113his-3 ad-6Neurospora crassa
FGSC #6114his-3 ad-6Neurospora crassa
FGSC #6115his-3 ad-6Neurospora crassa
FGSC #6116his-3 ad-6Neurospora crassa
FGSC #6117his-3 ad-6Neurospora crassa
FGSC #6118his-3 ad-6Neurospora crassa
FGSC #6119his-3 ad-6Neurospora crassa
FGSC #6120his-3 ad-6Neurospora crassa
FGSC #6121his-3 ad-6Neurospora crassa
FGSC #6122his-3 ad-6Neurospora crassa
FGSC #6123his-3 ad-6Neurospora crassa
FGSC #6124his-3 ad-6Neurospora crassa
FGSC #6125his-3 ad-6Neurospora crassa
FGSC #6126his-3Neurospora crassa
FGSC #6127his-3Neurospora crassa
FGSC #6128his-3Neurospora crassa
FGSC #6129his-3Neurospora crassa
FGSC #6130his-3Neurospora crassa
FGSC #6131his-3Neurospora crassa
FGSC #6132his-3Neurospora crassa
FGSC #6133his-3Neurospora crassa
FGSC #6510his-3Neurospora crassa
FGSC #6511his-3Neurospora crassa
FGSC #6512his-3Neurospora crassa
FGSC #6513his-3Neurospora crassa
FGSC #6514his-3Neurospora crassa
FGSC #6515his-3Neurospora crassa
FGSC #6516his-3Neurospora crassa
FGSC #6517his-3Neurospora crassa
FGSC #6518his-3Neurospora crassa
FGSC #6519his-3Neurospora crassa
FGSC #6520his-3Neurospora crassa
FGSC #6521his-3Neurospora crassa
FGSC #6522his-3Neurospora crassa
FGSC #6523his-3Neurospora crassa
FGSC #6524his-3Neurospora crassa
FGSC #6525his-3Neurospora crassa
FGSC #6526his-3Neurospora crassa
FGSC #6527his-3Neurospora crassa
FGSC #6528his-3Neurospora crassa
FGSC #6529his-3Neurospora crassa
FGSC #6530his-3Neurospora crassa
FGSC #6531his-3Neurospora crassa
FGSC #6532his-3Neurospora crassa
FGSC #6533his-3Neurospora crassa
FGSC #6560his-3Neurospora crassa
FGSC #6561his-3Neurospora crassa
FGSC #6562his-3Neurospora crassa
FGSC #6693his-3Neurospora crassa
FGSC #6694his-3Neurospora crassa
FGSC #6695his-3Neurospora crassa
FGSC #6696his-3Neurospora crassa
FGSC #6697his-3Neurospora crassa
FGSC #6698his-3Neurospora crassa
FGSC #7088his-3Neurospora crassa
FGSC #7487his-3;bd;ccg-1RIPNeurospora crassa
FGSC #7505mep-1, his-3;mtr;pan-2Neurospora crassa
FGSC #7506mep-1, his-3;mtr;pan-2Neurospora crassa
FGSC #7507his-3 cyh-1 al-1;mtr;inlNeurospora crassa
FGSC #7508his-3 cyh-1 al-1;mtr;inlNeurospora crassa
FGSC #8324mat delta A::ADE5 his-3; inlNeurospora crassa
FGSC #8325mat delta A::ADE5 his-3; thi-4 ad-2Neurospora crassa
FGSC #8326mat delta A::ADE5 his-3Neurospora crassa
FGSC #8329mat delta A::ADE5 his-3; delta am::mat-ANeurospora crassa
FGSC #8373his-3 cyh-1; Bml[r]; inlNeurospora crassa
FGSC #8374his-3 cyh-1; Bml[r]; inl a[m33]Neurospora crassa
FGSC #8387his-3; agaNeurospora crassa
FGSC #8388his-3; aga; spe-1::hphNeurospora crassa
FGSC #8594his-3; dim-2::hphNeurospora crassa
FGSC #8629cax-RIP his-3Neurospora crassa
FGSC #8747mat^delta his-3; {hyg^R tk^+(FUDR^s)} Bml pan-2Neurospora crassa
FGSC #8748mat^delta his-3; inl; Bml pan-2Neurospora crassa
FGSC #8914mepR(10) his-3; inl^[(SadI-BglII)::lambda A]Neurospora crassa
FGSC #9001bd his-3 wc-1^koNeurospora crassa
FGSC #9012cac-1^rip1 his-3Neurospora crassa
FGSC #9014rid his-3Neurospora crassa
FGSC #9015rid his-3Neurospora crassa
FGSC #9016hH1; his-3Neurospora crassa
FGSC #9017hH1; his-3Neurospora crassa
FGSC #9538mus-51 delta::Bar; his-3Neurospora crassa
FGSC #9539mus-52 delta::Bar; his-3Neurospora crassa
FGSC #9540mus-51 delta::Bar; T(I->V)AR190 his-3 nic-2 cyh-1 al-1Neurospora crassa
FGSC #9541mus-52 delta::Bar; T(I->V)AR190 his-3 nic-2 cyh-1 al-1Neurospora crassa
FGSC #4771Not available rg-1, his-3, nic-2Neurospora crassa
FGSC #9716his-3Neurospora crassa
FGSC #9717delta mus-51::bar+; his-3Neurospora crassa
FGSC #9720delta mus-52::bar+; his-3Neurospora crassa
FGSC #12202NCU03493.2 (het-c) his-3Neurospora crassa
FGSC #10210ncu09106.1::hph, his-3 bdNeurospora crassa
FGSC #10680his-3 ham10^rip3 (NCU02833)Neurospora crassa
FGSC #10681his-3; atg8^rip2 (NCU01545)Neurospora crassa
FGSC #10682his-3; atg8^rip1 (NCU01545)Neurospora crassa
FGSC #10683his-3 ham10^rip2 (NCU02833)Neurospora crassa
FGSC #10684his-3 ham10^rip1 (NCU02833)Neurospora crassa
FGSC #26695his-3; ash1-3xFLAG::hphNeurospora crassa
FGSC #26696his-3; ash1(Y888F)-3xFLAG::hph; mus-52::barNeurospora crassa
FGSC #26697his-3; ash1(Y888F)-3xFLAG::hphNeurospora crassa
FGSC #26698his-3; ash1(Y888F)-3xFLAG::hphNeurospora crassa
FGSC #26699his-3; ash1(Y888F)-3xFLAG::hphNeurospora crassa
FGSC #26704set-2::nat; ash1(Y888F)-3xFLAG::hph; his-3; mus-52::barNeurospora crassa
FGSC #26705set-2::nat; ash1(Y888F)-3xFLAG::hph; his-3Neurospora crassa

References

Authors Title Year
Ahmed, A.Organization of the histidine-3 region of Neurospora.1968
Ahmed, A. , M. E. Case, and N. H. Giles.The nature of complementation among mutants in the histidine-3 region of N. crassa.1964
Angel, T. , B. Austin, and D. G. Catcheside.Regulation of recombination at the his-3 locus in N. crassa.1970
Benson, E. W. , and H. B. Howe, Jr.Reversion and interallelic complementation at four urease loci in N. crassa.1978
Catcheside, D. G.Complementation among histidine mutants of N. crassa.1960
Catcheside, D. G.Multiple enzymic functions of a gene in Neurospora crassa.1965
Catcheside, D. G. , and T. Angel.A histidine-3 mutant,in Neurospora crassa, due to an interchange.1974
Catcheside, D. G. , and B. Austin.The control of allelic recombination at histidine loci in N. crassa.1969
Catcheside, D. G. , and D. Corcoran.Control of non-allelic recombination in N. crassa.1973
Creaser, E. H. , and M. Gardiner.Proteins immunologically related to Neurospora histidinol dehydrogenase.1969
De Serres, F. J.Comparison of the complementation and genetic maps of closely linked nonallelic markers on linkage group I ofNeurospora crassa.1969
Haas, F. , M. B. Mitchell, B. N. Ames, and H. K. Mitchell.A series of histidineless mutants of Neurospora crassa.1952
Minson, A. C. , and E. H. Creaser.Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, fromNeurospora crassa.1969
Webber, B. B.Genetical and biochemical studies of histidine-requiring mutants of Neurospora crassa. III. Correspondence betweenbiochemical characteristics and complementation map position of his-3 mutants.1965
Webber, B. B.Genetical and biochemical studies of histidine-requiring mutants of Neurospora crassa. IV. Linkage relationships ofhis-3 mutants.1965
Webber, B. B. , and M. E. Case.Genetical and biochemical studies of histidine-requiring mutants of Neurospora crassa. I. Classification of mutants and characterization of mutant groups.1960
Webber, B. B. , and H. V. Malling.Relation between complementation pattern and genetic alteration in his-3 mutants of Neurospora.1967
Dubins et al1989

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