lactose nonutilization

locus: lac

locus_name: lactose nonutilization

organism_type: B

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cultural_requirements: Multigenic basis. No major gene identified. Strains designated lac showed poor growth on lactose. Lactase (beta-D-galactosidase) properties were unaltered; levels were normal when grown on sucrose and depressed on lactose (584, 585). These strains differ from wild type at several loci, each with a small and additive effect on lactose utilization; e.g., three component genes from "lac-" strain 31389 x wild type were shown to be unlinked and were designated n-lac-1, pow(n-lac-2) (powdery conidia), and floc(nlac-3) (flocculent morphology). These genes are not specific for lactose utilization but also result in an altered adaptation response to other carbon sources and in other pleiotropic effects. Thus, probably no identified locus qualifies to be designated lac. (357) The failure to find a single gene mutant unable to use lactose is ascribed to the fact that Neurospora has two beta-galactosidases (605 and references therein).

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Strains

References