lysine-3

locus: lys-3

locus_name: lysine-3

organism_type: B

chromosome_number: I

chromosome_side: R

link_group: IR

cultural_requirements: IR. Right of al-1 (9%) and al-2 (12 to 15%). Left of In(OY323) and nic-1 (<1%) (2, 907). Not included in duplications from In(OY323) x In(NM176); hence, left of ace-3(57). (288)Uses lysine or epsilon-hydroxynorleucine. Probably blocked in conversion of alpha-aminoadipate to alpha-aminoadipate semialdehyde, based on precursor utilization (400, 1087) (Fig. 16). Complementation between alleles (13). Ascospores are white and inviable in homozygous lys-3 x lys-3 crosses, but some heteroallelic crosses are fertile (13). Inhibited by methionine. Initial allele: 4545.

enzyme_id: 202

Enzyme: none

anid_name:

near_l: al-1 (9%) and al-2 (12 to 15%)

near_r: and nic-1 (<1%)

neu_name:

supplement: lysine orepsilon-hydroxynorleucine

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #327	(fz;sg;arg-1 cr-1 al1 os-1+ al2 nic-1 lys-3 os-1)	Neurospora crassa
FGSC #540	lys-3	Neurospora crassa
FGSC #974	lys-3	Neurospora crassa
FGSC #4302	lys-3	Neurospora crassa
FGSC #7231	al-1 lys-3	Neurospora crassa

References

Authors	Title	Year
Ahmad. M.	A study of the lys-3 locus in N. crassa.	1964
Ahmad, M. , A. Mozmadar, A. Baset, M. Fayaz, M. A. Rahman, and B. C. Saha.	Studies on the organization of genes controlling lysinebiosynthesis in N. crassa. III. Studies on the organization of loci lys-3 and lys-4.	1979
Barry, E. G. , and J. F. Leslie.	An interstitial pericentric inversion in Neurospora.	1982
Doermann, A. H.	Investigations of the lysine-requiring mutants of Neurospora crassa.	1946
Good, N. , R. Heilbronner, and H. K. Mitchell.	epsilon-Hydroxynorleucine as a substitute for lysine for Neurospora.	1950
St. Lawrence, P.	The q locus of Neurospora crassa.	1956
Trupin, J. S. , and H. P. Broquist.	Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 1. Studies inNeurospora crassa.	1965