modifier of permeability

locus: mod-5

locus_name: modifier of permeability

organism_type: B

chromosome_number: VI

chromosome_side:

link_group: VI

cultural_requirements: VI. Linked to trp-2, near the centromere (3%) (909). Improves growth of trp-1, trp-2, trp-3, trp-4, aro-1, tyr-1, tyr-3, pt, met-7, and pyr-1 strains on complex media. Increases sensitivity to 4-methyltryptophan and p-fluorophenylalanine. Recessive in heterokaryons. Attributed to permeability change that facilitates entry of metabolites (53, 909). Scorable on slants of minimal medium plus 4-methyl-DL-tryptophan (0.9 mg/ml, autoclaved; tests read at 7 days 34 C) (PB). Map location similar to that of mts, but not tested for allelism. mts differs in not allowing the mutant pyr-1 (H263) to grow on complex media (160). (Locus symbols mod-1, -2, -3, and -4 have not been used.)

enzyme_id:

anid_name:

near_l: Linked to trp-2, near the centromere (3%)

near_r:

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #1603	mod-5	Neurospora crassa

References

Authors	Title	Year
Barratt, R. W. , and P. St. Lawrence.	Antimetabolite inhibition of mod-5.	1969
Catcheside, D. E. A.	A pleiotropic mutation in Neurospora conferring sensitivity to analogues of amino acids, purines andpyrimidines.	1978
St. Lawrence, P. , B. D. Maling, L. Altwerger, and M. Rachmeler.	Mutational alteration of permeability in Neurospora:effects ofgrowth and the uptake of certain amino acids and related compounds.	1964