uracil salvage-3

locus: uc-3

locus_name: uracil salvage-3

organism_type: B

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cultural_requirements: Unmapped. Thymidine salvage pathway defect (Fig. 23). Unable to use thymidine, thymine, or hydroxy-methylcytosine, but can use deoxyuridine, 5-formyluracil, uracil, or uridine to support growth of pyr-4 when uc-1 is also present. Excretes thymine into the medium when grown in the presence of thymidine (1141). Lacks thymine 7-hydroxylase, which catalyzes the reactions thymine -> 5-hydroxymethyluracil -> 5-formyluracil -> uracil-5-carboxylic acid; apparently, there is an alternate enzyme for 5-formyluracil -> uracil-5-carboxylic acid, which explains the growth on 5-formyluracil (616, 977).

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Strains

FGSC #	Reporting Genes	Species
FGSC #2198	uc-3	Neurospora crassa
FGSC #2204	uc-1;uc-3;pyr-4	Neurospora crassa
FGSC #2205	pyr-1;uc-3	Neurospora crassa

References

Authors	Title	Year
Liu, C. -K. , C. -A. Hsu, and M. T. Abbott.	Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase.	1973
Shaffer, P. M. , C. -A. Hsu, and M. T. Abbott.	Metabolism of pyrimidine deoxyribonucleosides in Neurospora crassa.	1975
Williams, L. G. , and H. K. Mitchell.	Mutants affecting thymidine metabolism in Neurospora crassa.	1969