guanine nucleotide-alpha-1

locus: gna-1

locus_name: guanine nucleotide-alpha-1

organism_type: B

chromosome_number: III

chromosome_side: R

link_group: IIIR

cultural_requirements: IIIR. Linked to ro-2 (0/17). Encodes guanine nucleotide-binding protein alpha-1-subunit. The predicted amino acid sequence shows significant homology to the Gi family found in higher organisms. The null mutant shows female infertility, osmotic sensitivity, reduced hyphal growth rate, and defective macroconidiation, has decreased intracellular cAMP levels, and is more resistant to some environmental stresses than wild type. Mutants that are predicted to maintain an activated state of GNA-1 have increased intracellular cAMP levels, overproduce aerial hyphae, and are more sensitive to environmental stresses than wild type. Null-mutant extracts have reduced Mg^2+ -dependent adenylyl cyclase and cAMP phosphodiesterase activity. Mg^2+ -dependent adenylyl cyclase activity in wild-type extracts can be inhibited by using antibody against GNA-1.

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Strains

FGSC #	Reporting Genes	Species
FGSC #9428	cot-1;gna-1	Neurospora crassa
FGSC #9445	smco-7;gna-1	Neurospora crassa
FGSC #9449	col-16 gna-1	Neurospora crassa
FGSC #9450	gna-1 col-15	Neurospora crassa
FGSC #9453	spco-4;gna-1	Neurospora crassa
FGSC #9454	col-4;gna-1	Neurospora crassa

References

Authors	Title	Year