canavanine resistant

locus: cnr

locus_name: canavanine resistant

organism_type: B

chromosome_number: I

chromosome_side: R

link_group: IR

cultural_requirements: IR. Linked to hom (1%) and nic-1 (11%), probably between them (812). (1061) Resistance to canavanine (480, 1061, 1062) is due to a constitutive enzyme that cleaves L-canavanine to hydroxyguanidine plus a compound which can be converted to L-homoserine (617). Resistance is altered secondarily by modifiers that affect rate of uptake (617). Many laboratory strains are resistant, but a few are sensitive (790). Best scored on 0.2 mg of L-canavanine H2SO4 per ml (autoclaved in the medium) at 2 days, 34°C (812; D.D. Perkins, unpublished data). Sensitive strain used to select resistant mutants defective in basic amino acid transport (889, 913, 1152); see pmb. Called can.

enzyme_id: 202

Enzyme: none

anid_name:

near_l: hom (1%)

near_r: nic-1 (11%) probably between them

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #263	al-2 cnr	Neurospora crassa

References

Authors	Title	Year
Horowitz, N. H. , and A. M. Srb.	Growth inhibition of Neurospora by canavanine, and its reversal.	1948
Logan, J. B.	Biochemistry and genetics of canavanine resistance in Neurospora.	1969
Perkins, D. D.	Incidence of cananavine sensitivity in Neurospora.	1960
Perkins, D. D. , M. Glassey, and B. A. Bloom.	New data on markers and rearrangements in Neurospora.	1962
Roess, W. B. , and A. G. DeBusk.	Properties of a basic amino acid permease in Neurospora crassa.	1968
Sanchez, S. , L. Martinez, and J. Mora.	Interactions between amino acid transport systems in Neurospora crassa.	1972
Teas, H. J.	The biochemistry and genetics of threonine requiring mutants of Neurospora crassa.	1947
Teas, H. J.	Effect of canavanine on mutants of Neurospora and Bacillus subtilis.	1951
Wolfinbarger, L. , Jr. , and A. G. DeBusk.	Molecular transport. I. In vivo studies of transport mutants of Neurospora crassa withaltered amino acid competition patterns.	1971