cytochrome-18

locus: cyt-18

locus_name: cytochrome-18

organism_type: B

chromosome_number: I

chromosome_side: R

link_group: IR

cultural_requirements: IR. Linked to al-2 (10%) and nic-1 (1 to 5%) (203, 635).Heat sensitive; grows slowly. Deficient in cytochromes aa3 and b at 37°C (832). Mitochondrial protein synthesis and assembly of small mitochondrial subunits are also abnormal (205). A novel large RNA precursor (35S) is found at restrictive temperatures (205); the intervening sequence of large (25S) mitochondrial rRNA is apparently not excised. Two alleles (289-67, 299-9) differ in speed of turn-off of RNA processing when the temperature is shifted (635). Complements cyt-4 and cyt-19, which are also required for splicing of large mitochondrial rRNA (83).

enzyme_id: 136

Enzyme: mitochondrial tyrosyl-tRNA synthetase

anid_name:

near_l: Linked to al-2 (10%) and nic-1 (1 to 5%)

near_r:

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #5062	cyt-18 al-2	Neurospora crassa

References

Authors	Title	Year
Bertrand, H. , P. Bridge, R. A. Collins, G. Garriga, and A. M. Lambowitz.	RNA splicing in Neurospora mitochondria. Characterization of new nuclear mutants with defects in splicing the mitochondrial large ribosomal RNA.	1982
Collins, R. A.	Mitochondrial assembly in wild type and mutant strains of N. crassa.	1979
Collins, R. A. , H. Bertrand, F. J. La Polla, and A. M. Lambowitz.	Mitochondrial ribosome assembly in N. crassa:mutants with defectsin mitochondrial ribosome assembly.	1979
Drake, B.	Evidence for two loci governing para-aminobenzoic acid synthesis in Neurospora crassa.	1956
Eberhart, B. M. , and R. S. Beck.	Localization of the beta-glucosidases in Neurospora crassa.	1970
Mannella, C. A. , R. A. Collins, M. R. Green, and A. M. Lambowitz.	Defective splicing of mitochondrial rRNA in cytochrome- deficientnuclear mutants of Neurospora crassa.	1979
Pittenger, T. H. , and D. J. West.	Isolation and characterization of temperature-sensitive respiratory mutants of Neurospora crassa.	1979
Akins and Lambowitz		1987