Gene: leucine-2 IVR
leucine-2
locus: leu-2
locus_name: leucine-2
organism_type: B
chromosome_number: IV
chromosome_side: R
link_group: IVR
cultural_requirements: IVR. Between trp-4 (2%) and ilv-3 (4%) (579, 991). (D.C. Regnery, cited in reference 633)Requires leucine (867, 868). Structural gene for isopropylmalate isomerase (432, 871) (Fig. 15). Altered heat inactivation of hybrid enzymes (432). Structural differences of hybrid enzymes (871). Accumulates alpha-isopropylmalate (427). Synthesis of the enzyme also requires the function of regulatory gene leu-3+ and the presence of alpha-isopropylmalate, which acts as an inducer (427). Resistant to aminotriazole (D.D. Perkins, unpublished data). Alleles show intralocus complementation (424). Allele 37501 is heat sensitive (30°C versus 20 C) and is leaky at 25°C (D.C. Regnery, personal communication).
enzyme_id: 129
Enzyme: isopropylmalate isomerase
anid_name:
near_l: trp-4 (2%)
near_r: ilv-3 (4%)
neu_name:
supplement: leucine
image_url:
Strains
References
