FGSC #4817

Mutant Type

Genus: N

reporting_genes: leu-2

species: Neurospora crassa

allele: 37501

stock:

glasgow:

mutagen:

Depositor: RMD

Link Group: IVR

MT: a

Species No: 10

gene_back: M

oppmt: 4816

trans:

ref1: Maling 1959 Genetics 44:1215-1220, https://www.genetics.org/content/44/6/1215.long

ref2:

site:

country:

ksudc_link: https://digital.lib.k-state.edu/item/neurospora-crassa/fgsc-4817

Locus	Cultural Requirements	Link Group	Type
leu-2	IVR. Between trp-4 (2%) and ilv-3 (4%) (579, 991). (D.C. Regnery, cited in reference 633)Requires leucine (867, 868). Structural gene for isopropylmalate isomerase (432, 871) (Fig. 15). Altered heat inactivation of hybrid enzymes (432). Structural differences of hybrid enzymes (871). Accumulates alpha-isopropylmalate (427). Synthesis of the enzyme also requires the function of regulatory gene leu-3+ and the presence of alpha-isopropylmalate, which acts as an inducer (427). Resistant to aminotriazole (D.D. Perkins, unpublished data). Alleles show intralocus complementation (424). Allele 37501 is heat sensitive (30°C versus 20 C) and is leaky at 25°C (D.C. Regnery, personal communication).	IVR	B

Neurospora Crassa Wikipedia