Gene: meiotic-1 IVR
meiotic-1
locus: mei-1
locus_name: meiotic-1
organism_type: B
chromosome_number: IV
chromosome_side: R
link_group: IVR
cultural_requirements: IVR. Linked to arg-2 (<1%), probably to the right (995). Meiosis is impaired in homozygous crosses. Recessive. Meiotic divisions occur and many ascospores are produced, but 70 to 90% are inviable and white. The viable ascospores are usually disomic for one or more linkage groups, indicating high nondisjunction at the first division (254, 995). Chromosome pairing is defective: axial elements of synaptonemal complex are present, but a completed complex is rarely seen. Separation at anaphases I and II is defective, leading to four-poled second and third division spindles (625). Not sensitive to UV, methyl methane sulfonate, ionizing radiation (939), or histidine (939; D. Newmeyer, unpublished data). mei-1 is present in wild-collected strain Abbott 4A (995), which is an ancestor of many Beadle and Tatum mutants (68). Possible allele asc(DL243)complements mei-1 but did not recombine with it (0/3,000) (253). DL243 and mei-1 strains differ phenotypically. In DL243 mutants, the major block is before karyogamy; the few asci produced have normal meiosis I but high nondisjunction at meiosis II, with most chromosomes usually attached to only one spindle-pole body (254). Possible allele asc(DL95) complements mei-1 and asc(DL243), but did not recombine with DL243 (0/96) (253). DL95 is phenotypically like mei-1 but is less extreme (254).
enzyme_id:
anid_name:
near_l: Linked to arg-2 (<1%)
near_r:
neu_name:
supplement:
image_url:
Strains
| FGSC # | Reporting Genes | Species |
|---|---|---|
| FGSC #176 | Not available; T(I;IV)HK53 cut mei-1 | Neurospora crassa |
| FGSC #2067 | Has been replaced by strain number: 2272 | Neurospora crassa |
| FGSC #2919 | mei-1 | Neurospora crassa |
| FGSC #2920 | mei-1 | Neurospora crassa |
| FGSC #7280 | ad-1;am132 inl inv mei-1 | Neurospora crassa |
References
