Gene: ornithine transaminase IIIR
ornithine transaminase
locus: ota
locus_name: ornithine transaminase
organism_type: B
chromosome_number: III
chromosome_side: R
link_group: IIIR
cultural_requirements: IIIR. Between ad-4 (15%) and tyr-1 (14%) (241). Linked to pro-4 (4%) (D.J. West, cited in Neurospora Newsl. 16:19-22, 1970). Ornithine-delta-transaminase deficient (241) (Fig. 10). Conidiates somewhat less than does the wild type (S. Brody, personal communication). Selected by ability to use exogenous ornithine as a precursor for arginine in an arg-5 arg-12s double mutant. Catabolism of ornithine (to glutamic-gamma-semialdehyde) is blocked, resulting in ornithine concentrations high enough to compensate for the low activity of the ornithine carbamyl transferase in the arg-12s mutant. The ota single mutant is prototrophic but prevents the efficient use of ornithine or arginine as the sole nitrogen source (241). Used to study flux through the arginine biosynthetic pathway (401). Used to study the utilization of endogenous versus exogenous ornithine (234). Sideramine production is completely blocked in absence of ornithine in the ota;arg-5;aga triple mutant, which is used to study iron transport (1146, 1147).
enzyme_id: 145
Enzyme: ornithine transaminase
anid_name: ota
near_l: ad-4 (15%)
near_r: tyr-1 (14%)
neu_name:
supplement:
image_url:
Strains
| FGSC # | Reporting Genes | Species |
|---|---|---|
| FGSC #1523 | Has been replaced by strain number: 1700 | Neurospora crassa |
| FGSC #1700 | ota | Neurospora crassa |
| FGSC #1701 | ota | Neurospora crassa |
| FGSC #2744 | arg-5;ota;aga | Neurospora crassa |
| FGSC #4218 | sit-5;ota | Neurospora crassa |
| FGSC #4219 | sit-2;sit-3;ota | Neurospora crassa |
| FGSC #4220 | set-2;sit-3;arg-5;ota | Neurospora crassa |
| FGSC #4224 | sit-2;sit-5;ota | Neurospora crassa |
| FGSC #4225 | sit-2;sit-5;arg-5;ota | Neurospora crassa |
| FGSC #4228 | sit-4;sit-5;arg-5;ota | Neurospora crassa |
| FGSC #4229 | sit-4;sit-5;arg-5;ota | Neurospora crassa |
References
