FGSC #2702

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Reporting Genes: xdh-1

Species: crassa

Allele: NMR11

Alternate Strain Number: 197

Mutagen: UV

Depositor: GAM

Linkage Group: II

Mating Type: A

Species Number: 10

Genetic Background: SL

ref1: Reinert & Marzluf 1975 Molec gen Genet 139:39-55, https://doi.org/10.1007/bf00267994

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
xdh-1	II. Linked to pe (14%) and alc-1 (24%) (872). Defective in purine catabolism. Unable to use hypoxanthine as the sole nitrogen source. Lacks xanthine dehydrogenase (xanthine oxidase) (872) (Fig. 24). nit-1, -7, -8, and -9 mutants are also deficient in xanthine dehydrogenase activity because of a defect in the molybdenum containing cofactor that is common to xanthine dehydrogenase and nitrate reductase (741, 1080, 1081). Purine catabolic pathway, showing the sites of action of the xdh, aln, alc, and uregenes (452, 569, 872). The molybdenum cofactor is essential to both xanthine dehydrogenase and nitrate reductase	II	B