xanthine dehydrogenase-1

locus: xdh-1

locus_name: xanthine dehydrogenase-1

organism_type: B

chromosome_number: II

chromosome_side:

link_group: II

cultural_requirements: II. Linked to pe (14%) and alc-1 (24%) (872). Defective in purine catabolism. Unable to use hypoxanthine as the sole nitrogen source. Lacks xanthine dehydrogenase (xanthine oxidase) (872) (Fig. 24). nit-1, -7, -8, and -9 mutants are also deficient in xanthine dehydrogenase activity because of a defect in the molybdenum containing cofactor that is common to xanthine dehydrogenase and nitrate reductase (741, 1080, 1081). Purine catabolic pathway, showing the sites of action of the xdh, aln, alc, and uregenes (452, 569, 872). The molybdenum cofactor is essential to both xanthine dehydrogenase and nitrate reductase

enzyme_id: 197

Enzyme: xanthine dehydrogenase

anid_name: hxA

near_l: Linked to pe (14%) and alc-1 (24%)

near_r:

neu_name:

supplement:

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #2702	xdh-1	Neurospora crassa
FGSC #2703	xdh-1	Neurospora crassa

References

Authors	Title	Year
Haysman, P. , and H. B. Howe, Jr.	Some genetic and physiological characteristics of urease-defective strains of Neurospora crassa.	1971
Kolmark, H. G.	Urease defective mutants in Neurospora crassa.	1969
Nason, A. , K. -Y. Lee, S. -S. Pan, P. A. Ketchum, A. Lamberti, and J. De Vries.	In vitro formation of assimilatory reduced nicotinamideadenine dinucleotide phosphate:nitrate reductase from a Neurospora mutant and a component of molybdenum-enzymes.	1971
Reinert, W. R. , and G. A. Marzluf.	Genetic and metabolic control of the purine catabolic enzymes of Neurospora crassa.	1975
Tomsett, A. B. , and R. H. Garrett.	The isolation and =770a. characterization of mutants defective in nitrate assimilation in Neurosporacrassa.	1980
Tomsett, A. B. , and R. H. Garrett.	Biochemical analysis of mutants defective in nitrate assimilation in Neurospora crassa:evidencefor autogenous control of nitrate reductase.	1981
Griffith and Garrett		1988