sulfonamide dependent

locus: sfo

locus_name: sulfonamide dependent

organism_type: B

chromosome_number: VII

chromosome_side:

link_group: VII

cultural_requirements: Linked to the centromere (<1%) (318), between thi-3 (6%) (874) and hlp-1(1 to 9%) (458). Requires sulfonamide at 35°C and is stimulated by sulfonamide at lower temperatures (319). Overproduces p-aminobenzoic acid; hence, growth is inhibited by exogenous p-aminobenzoic acid (1179). For sfo;pab-1 double mutant on minimal medium plus sulfonamide, p-amino-benzoic acid is stimulatory at very low concentrations but inhibitory at higher (319). For sfo;met-1 double mutant on minimal medium plus sulfonamide, methionine is stimulatory at very low concentrations but inhibitory at higher (1180). Best tested on solid minimal medium growth tubes at 35°C. Suppressor mutations occur frequently (318).

enzyme_id:

anid_name:

near_l: thi-3 (6%)

near_r: hlp-1(1 to 9%);Linked to the centromere (<1%)

neu_name:

supplement: sulfonamide

image_url:

Strains

FGSC #	Reporting Genes	Species
FGSC #506	sfo	Neurospora crassa
FGSC #576	sfo nt	Neurospora crassa
FGSC #651	sfo	Neurospora crassa
FGSC #652	sfo	Neurospora crassa

References

Authors	Title	Year
Emerson, M. R. , and S. Emerson.	The sulfonamiderequiring character (sfo) as a marker for chromosome VII of Neurospora crassa.	1951
Emerson, S.	Growth responses of a sulfonamide-requiring mutant strain of Neurospora.	1947
Ho, C. C.	Mutants of Neurospora crassa permeable to histidinol.	1969
Reisner, A. , R. W. Barratt, and D. Newmeyer.	Confirmation of the seventh linkage group of Neurospora crassa.	1953
Zalokar, M.	The p-amino benzoic acid requirement of the "sulfonamide-requiring" mutant strain of Neurospora.	1948
Zalokar, M.	The sulfanomide-requiring mutant of Neurospora:threonine-methionine antagonism.	1950